A Bone Marrow Transplant: the Donating Process

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Cheek Swab Testing

Joining a Bone Marrow Registry

A potential donor’s initial contact with Ezer Mizion’s Bone Marrow Registry begins with a cheek swab sample. This will enable the registry to make a preliminary determination regarding the compatibility between the donor and a patient in need of a bone marrow transplant. His genetic information will remain on the database for decades, available for any patient whose DNA matches his. Some potential donors are contacted for further testing within a year of registration, others not for 10-20 years or not at all.

Once it had been determined that a donor is a possible genetic match, things move quickly. When a patient is in need of a bone marrow transplant, time is of essence. Further testing must be done and it cannot wait. Should the patient’s condition deteriorate, the transplant, his last chance to survive, may no longer be medically feasible.

Often, if a great deal of time has elapsed since registration, the contact info is no longer valid. The internet is then surfed until the donor is located. No effort is too much when a human life is involved.

The donor is then asked if he would like to donate. The procedure is entirely voluntary and the donor has the right to refuse at the outset or at any time. No persuasion is used leaving the decision completely up to the potential donor.

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Stem Cells

In most cases, it is a stem cell transplant rather than a bone marrow transplant that takes place. This is a much simpler procedure which results in a higher percentage of potential donors agreeing to go ahead.

What do we mean by genetic match?

Human leukocyte antigens (HLA) are proteins that are present in most body cells. These antigens help identify tissue types. The immune system utilizes HLA antigens in order to identify the cells that belong in your body and the cells that do not belong in your body. If the immune system detects cells that do not belong on your body, it will reject them, thus resulting in a failed transplant.

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Blood Samples Being Tested

HLA proteins are important in determining the compatibility of donors and patients for a stem cell transplant. In order to match tissue types for a transplant, the compatibility of ten of the donor and patient antigens are checked (generally, A, DR, C, B, and DQ).

Usually, a compatibility of at least 8 out of 10 antigens is necessary in order to approve a donor for a transplant.

In addition to the basic testing, Ezer Mizion’s Bone Marrow Registry is committed to supporting research to enhance results of transplants and the donor may be asked to participate in this research as part of the donation process. The decision whether to participate in the research is up to the donor.

Timing

Three weeks to several months may elapse until the patient’s attending doctor will come to a decision. The Registry staff will call the donor to inform him of the results of the compatibility confirmatory testing.

The donor may be asked to donate immediately or to wait until the patient is ready. Each case is different; the timing of the donation will be based upon what is best for the donor and for the patient. After a date has been set, the preparatory stage will continue.

At the preparatory stage before the donation, the donor will speak with the Registry staff in order to learn about the process and the risks and side effects involved in giving a donation. If he chooses to donate, he will undergo blood tests and a physical examination by a physician. A detailed questionnaire is also required in addition to a signed consent form.

 

Increasing Stem Cells in the Donor

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Donating Stem Cells

On the day of the transplant, blood is taken from the donor, much the same as if he were donating blood. The stem cells are harvested from the whole blood and the remainder returned to the donor through the second arm. The process is repeated for several hours until the required amount of stem cells (depending on the size of the patient) is obtained.  So that a large amount of stem cells be available, the donor receives neupogen injections several days before the transplant to stimulate the release of stem cells from the bone marrow into the blood stream.

 

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Life-saving bag of stem cells

The Transplant

When the required amount has been accumulated, the stem cells are then infused into the body of the patient through a central line, a painless procedure. Within 2 days to several weeks, the new cells will begin to produce red cells, white cells and platelets in place of the defective ones, thus producing a cure for many life-threatening diseases.

Bone Marrow Registry Anonymity

By international law, a registry must maintain confidentiality and strict non-disclosure of donor and patient information. This policy is for the protection of both the donor and the patient.

In order to maintain confidentiality of information, donors and patients receive an identification number. These ID numbers enable doctors to share important medical information without using names or addresses. This high level of privacy is maintained throughout the stages of the process.

Patients are informed only of the age and gender of their donor. Donors are told only of the age, gender, and disease of the recipient patient.

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You saved my life!
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You saved my life!

The patient’s identity may be revealed only after at least a year has elapsed from the date of donation and the patient has expressed his agreement to disclosure and a meeting. This meeting understandably will be highly emotional with the patient and his family trying to express the unexpressable: You saved my life!

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45 Years of Tears: The Bone Marrow Transplant that Never Was

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“Where were you 45 years ago when my son needed a bone marrow transplant?”

At Ezer Mizion’s busy office, the phone does not stop ringing. At times, it is the ubiquitous telemarketing call. Other calls may be requesting information about the bone marrow registry. Some calls can be as brief as several sentences but leave the staff member stunned. Like this one received by Chani :

“Where were you 45 years ago? When my son needed a bone marrow transplant? I took my two daughters to be tested at UCLA but they were not a genetic match.” Then her voice faltered, “Before we could try more people, my son— my son—- my son died.” Her voice broke but she tried to continue speaking, “I want to give you a donation. Your organization is so important.  I only wish it had been in existence 45 years ago. Perhaps he could have received a bone marrow transplant. Perhaps he could have been saved.” She was overcome by tears and hung up the phone.   The pain of losing a child does not disappear, even after 45 yrs. Continue reading 45 Years of Tears: The Bone Marrow Transplant that Never Was

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Because of You!

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November 2017 Bone Marrow Donor Registry

ACTIVITY SUMMARY
22 lifesaving transplants
14 from personalized donor pools
2,657 total transplants
877,315 members in registry
Below are the donor pools that saved lives this month, and their total transplants. Continue reading Because of You!

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A Hole in One

2017 Golf Closest to the Pin AK7X9484 (1)
Winner of Closest to the Pin: A Strike Against Cancer

Eight times! For eight years, Ezer Mizion has held its annual Thanksgiving Day Golf Tournament at Caesaria Golf Club in Israel. Golf aficionados gather for a day under the azure skies, each stroke being a strike against cancer. Many travel to Israel from abroad to join in the camaraderie of the event. Continue reading A Hole in One

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Can You Buy Life?

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A small child who will grow up because someone just like you cared enough to fund the DNA testing of his donor

$50…it can buy a lunch for two… a nice shirt…a tank of gas…or a child’s life. Yes. For fifty dollars, a tiny toddler with cancer can be genetically matched to a bone marrow donor and his life will be saved.

For many cancer patients, a bone marrow transplant is their sole chance of survival. To be successful, both donor and recipient must share the same DNA. Ezer Mizion, the largest Jewish Bone Marrow Registry in the world, has saved over 2500 lives of people around the world but too many are still waiting for the match that will mean life itself.

Parents of tiny toddlers, whose mischievous giggles have long given way to a pathetic whimper, sit for hours in the pediatric oncology ward. Teenagers refrain from joining their peers who are planning their futures since, for them, there may not be a future. Young mothers and fathers clutch their kids tightly, praying so hard that these precious children will not have to grow up as orphans.

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In the process of donating his stem cells so that another may live

Even the largest registry is not large enough. Your gift of $50 will help expand the registry. And then the phone at the home of one of these families may ring and a triumphant voice will announce: Yes! We have a match!

Click on the links  to share the joy of families who had despaired of seeing the sun shine again. Donate generously on #GivingTuesday so that other families may share that same joy!

 

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Because of You!

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October 2017 – BMDR ACTIVITY SUMMARY
29 lifesaving transplants
16 from personalized donor pools
2,635 total transplants
875,481 members in registry


Below are the donor pools that saved lives this month, and their total transplants. Continue reading Because of You!

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Because of You!

website bmr update template

 

 

September 2017 –  ACTIVITY SUMMARY
37 lifesaving transplants – our record for one month!
22 from personalized donor pools
2,606 total transplants
872,375 members in registry

Below are the donor pools that saved lives this month, and their total transplants. Continue reading Because of You!

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Because of You!

website bmr update template

 

 

23 lifesaving transplants
2,569 total transplants
865,626 members in registry
14 from personalized donor pools (see below) Continue reading Because of You!

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The Other End of the World? No Problem When It Comes to Saving Lives!

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No Jew Is Ever Alone When He is Linked to Life. Saving lives around the world.

“But he’s at the other end of the world!”

“No problem,” said the experienced Ezer Mizion staff member. “Just watch.” Continue reading The Other End of the World? No Problem When It Comes to Saving Lives!

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Ezer Mizion and The IDF: A Life-Saving Partnership

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Stem Cell Harvesting

In recent years, a bone marrow transplant has been proven to be the cure for a myriad of diseases.  Many forms of cancer including leukemia and lymphoma in addition to other diseases such as sickle cell anemia and SCID are only some of the life-threatening illnesses that have bowed to its power. Like penicillin, a bone marrow transplant can save lives. But unlike penicillin, it cannot simply be purchased at the local pharmacy.

WHY NOT? Continue reading Ezer Mizion and The IDF: A Life-Saving Partnership

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